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Molecular Basis of Inheritance Class 12 MCQs Questions with Answers
Multiple Choice Type Questions
Nucleic acids are polymer of
Answer: (d) Nucleotides
DNA structure was discovered by
(b) Watson and Crick
(c) Har Gobind Khorana
Answer: (b) Watson and Crick
Enzyme responsible for DNA replication
Answer: (a) Polymerase
(a) Functional unit of RNA
(b) Non-functional unit of RNA
(c) Functional unit of DNa that specifies a polypeptide chain
(d) Non-functional unit of DNA
Answer: (c) Functional unit of DNa that specifies a polypeptide chain
Transcription is the formation of
Answer: (a) mRNA
Which of the RNA is smallest and used in feeding of amino acid to a ribosome?
Answer: (b) tRNA
Initiation codon in higher plants is
Answer: (b) AUG
Synthesis of any protein in a cell is determined by
(a) Types of ribosomes
(c) Sequence of nucleotides in DNA
(d) Sugar and phosphate of DNA
Answer: (c) Sequence of nucleotides in DNA
The element required for the activation of DNA and DNA polymerase is
Answer: (b) Mg2+
The first gene isolated by shapiroet-al in 1969 was the gene of
(a) Insulin gene of .mouse
(b) Nitrogenase of cynobacteria
(c) Alamine of tRNA of yeast
(d) Lac operon of E.Coli
Answer: (d) Lac operon of E.Coli
Regulated unit of genetic material is called
(b) Operater gene
(c) Regulator gene
(d) Promoter gene
Answer: (a) Operon
Sickle cell anaemia is caused by change in
(a) A single base
(b) a chain of haemoglobin
(c) Frame shift mutation
(d) Whole ß chain of haemoglobin
Answer: (a) A single base
The mitochondrial DNA differs from nuclear DNA in
(а) Being linear
(b) Having A = T and C = G
(c) Being highly twisted
(d) Lacking binding of histones.
Answer: (d) Lacking binding of histones.
Which is required for protein synthesis?
(a) Initiation codon
(b) Peptidyl transferase
(d) All the above
Answer: (d) All the above
(a) Haploid chromosome set
(b) Complete chromosome set
(c) Diploid chromosome set
(d) AH the genes present in a population set
Answer: (a) Haploid chromosome set
As per template theory, amino acid first combines with
Answer: (a) tRNA
In DNa replication, the primer is
(a) A small deoxyribonucleotide polymer
(b) Small ribonucleotide polymer
(c) Helix destabilising protein
(d) Enzyme taking part in joining nucleotides to their complementary template bases.
Answer: (b) Small ribonucleotide polymer
The experimental system used in studies of discovery of replication of DNA has been
(a) Drosophila melanogaster
(c) Escherichia Coli
(d) Neurospora crassa
Answer: (c) Escherichia Coli
The approximate life span of mRNA is
(a) 2 hours
(b) 2 minutes
(c) 2 seconds
(d) None of the above
Answer: (b) 2 minutes
Topoisomerase is involved in
(a) Producing RNA primer
(b) Joining of DNA segment
(c) Producing nick in DNA
(d) Separation of DNA strands
Answer: (c) Producing nick in DNA
Fill in the Blanks
The DNA molecule takes a complete turn after every ……………….. base pairs.
Genes that shuffle from one location to another are called ………………..
Answer: jumping genes
The formation of a peptide bond is catalysed by the enzyme ………………..
Answer: peptidy, transferase
……………….. is the technique by which the three dimensional structures of macromolecules can be studied.
Answer: X-ray analysis
……………….. has the shape of clover-leaf.
……………….. is the process in which information is carried from RNA to DNA in some viruses.
Answer: Reverse transcription
New strands of DNA are formed only in the ……………….. direction.
Answer: 5′ → 3′ direction
One gene-one enzyme concept is now more accurately referred to as one ……………….. one ……………….. concept.
Answer: gene, polypeptide
……………….. are enzymes that unwind DNA helices while ……………….. break and reseal the strands.
Answer: Helicases, topoisomerases
The unidirectional flow of genetic information from DNA → RNA → protein is referred to as the ……………….. in molecular biology.
Answer: central dogma.
Write True or False
Genetic code is ambiguous.
RNA also serves catalytic functions.
Phosphodiester linkage is present in DNA.
DNA is basic in nature.
Histones are rich in lysines and arginines.
RNA being unstable, mutate at a faster rate.
In Eukaryotes, the DNA replication occurs at S-phase of cell cycle.
Cycloheximide prevent polypeptide chain elongation in eukaryotes but not in bacteria.
Extra nuclear DNA is found in Endoplasmic reticulum.
Genes are inert and can act in isolation.
One Word Questions
Who coined the word gene?
Write any two non-sense codons.
Answer: UGA, UAA.
How many bases code for one amino acid?
Name any organism where RNA acts as genetic material.
Who first deciphered the genetic code?
Answer: Nirenberg Ochoa, Hargobind Khorana and Francis Crick.
A nucleosome contains how many base pairs of DNA helix?
Answer: 200 base pairs.
What is genetic material?
Who suggested inborn errors in metabolism?
Answer: Archibold Garrod.
mRNA of eukaryotes is synthesized with the help of what?
Answer: RNA polymerase II.
Who proved experimentally that DNA replication is semi conservative?
Answer: Nesselson and Stahl.
Match the Following
|Column I||Column II|
|1. A retrovirus||A. One gene – one enzyme hypothesis|
|2. Splicing||B. Initiation codon|
|3. Beadle and Tatum||C. TMV|
|4. AUG||D. Non-sense codon|
|5. UAA||E. processing of mRNA molecules|
|Column I||Column II|
|1. A retrovirus||C. TMV|
|2. Splicing||E. processing of mRNA molecules|
|3. Beadle and Tatum||A. One gene – one enzyme hypothesis|
|4. AUG||B. Initiation codon|
|5. UAA||D. Non-sense codon|
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